ANTICORPS AYANT UNE MEILLEURE ACTIVITE CYTOTOXIQUE CELLULAIRE DEPENDANT DES ANTICORPS ET LEURS PROCEDES DE PRODUCTION ET LEUR UTILISATION

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专利权人:

GENZYME CORPORATION;GTC BIOTHERAPEUTICS, INC.

发明人:

申请号：

EP06844220.1

公开号：

EP1945666B1

申请日:

2006.10.23

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

The invention relates, in part, to antibodies with increased ADCC activity. Methods of producing such antibodies are also provided. The antibodies of the invention are produced in mammary epithelial cells, such as those in a non-human transgenic animal engineered to express and secrete the antibody in its milk. The antibodies or compositions comprising the antibodies can be used to treat disease in which ADCC activity provides a benefit. In one embodiment, therefore, the antibodies or compositions comprising the antibodies can be used to treat cancer, lymphoproliferative disease or autoimmune disease.

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中国工程科技知识中心

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http://www.ckcest.cn/home/