The present invention relates to the amino acid sequences for being directed to RANK-L, and including one or more amino acid sequences or consisting essentially of compound or construct and especially albumen and polypeptide. The invention further relates to the nucleic acid for encoding the amino acid sequence and polypeptide, the method for preparing the amino acid sequence and polypeptide with what； Expression or the host cell that the amino acid sequence or polypeptide can be expressed； Composition including the amino acid sequence, polypeptide, nucleic acid and/or host cell and especially pharmaceutical composition； With the application of the amino acid sequence or polypeptide, nucleic acid, host cell and/or composition, especially prevent, treat or the application of diagnostic purpose.本發明涉及針對RANK‑L的氨基酸序列，以及包括一個或多個所述氨基酸序列或基本上由其組成的化合物或構建體、且特別是蛋白和多肽。本發明還涉及編碼所述氨基酸序列和多肽的核酸，用於製備所述氨基酸序列和多肽的方法；表達或能够表達所述氨基酸序列或多肽的宿主細胞；包括所述氨基酸序列、多肽、核酸和／或宿主細胞的組合物、且特別是藥物組合物；和所述氨基酸序列或多肽、核酸、宿主細胞和／或組合物的應用，特別是預防、治療或診斷目的的應用。
