Industry - University Cooperation Foundation Hanyang University
发明人:
YUN, Chae Ok,AHN, Hyo Min
申请号：
EP16842279
公开号：
EP3329934A4
申请日:
2016.08.31
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention relates to an oncolytic adenovirus co-expressing interleukin (IL-12) and shVEGF and a composition for enhancing an anticancer effect. The inventors confirmed that, when VEGF suppression and IL-12 expression are co-expressed in immunocompetent murine melanoma or kidney cancer models, an immune function is restored and an anticancer effect is improved. Particularly, it has been revealed that such an improved anticancer effect is associated with an increase in anticancer immunity, an increase in Th1 cytokines and prevention of tumor-induced thymic atrophy, and therefore the applicability of a gene delivery system co-expressing IL-12 and shVEGF to cancer gene therapy was identified for the first time.
