Jae-Young PARK,Eun Mi HWANG,Heh-In IM,Chang-Hoon CHO,Sangjoon LEE
申请号：
US16643184
公开号：
US20200187467A1
申请日:
2018.07.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to: A schizophrenia animal model wherein the model is a mouse in which an anoctamin 1 (ANO1) gene is knocked out in cholinergic neurons of a medial habenula； and a preparation method therefor and the like. The schizophrenia animal model according to the present invention targets the medial habenula which is brain tissue playing a major role in the pathogenesis of schizophrenia, and it has been confirmed that when the ANO1 gene is specifically knocked out in the cholinergic neurons of the medial habenula, positive, negative and cognitive symptoms of schizophrenia are observed, thereby confirming that schizophrenia has been induced. Therefore, the animal model of the present invention is expected to be effectively useful in schizophrenia pathogenesis research and therapeutic agent development and screening.
