A method of continuously reducing the circulating level of insulin like growth factor 1 (IGF-1) in the first few months of the life of an infant comprises administering to the 5 infant a nutritional composition comprising proteins in an amount such that the composition contains less than 2.25 g of protein per 100 kcal. As IGF-1 is known to be a key control point in nutritional regulation of growth, this may offer a method of reducing the risk of developing obesity in later life.本發明係關於一種持續降低嬰兒出生後幾個月中類胰島素生長因子1(IGF－1)循環量之方法，其包含投予該嬰兒包含一定量之蛋白質的營養組合物，該組合物含有每100千卡低於2.25克之蛋白質。由於已知IGF－1在生長之營養調節中為一關鍵控制點，因而本發明可提供一種減少日後發展成肥胖症之風險的方法。
