The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and a bispecific antigen binding molecule that binds to PD-1 and Tim-3. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.本發明大體上係關於免疫結合物,特定言之,包含突變型介白素-2多肽及結合至PD-1與Tim-3之雙特異性抗原結合分子的免疫結合物。另外,本發明係關於編碼免疫結合物的聚核苷酸分子,以及包含此類聚核苷酸分子的載體及宿主細胞。本發明另外關於製備突變型免疫結合物的方法、包含其的醫藥組合物,及其用途。