VECTEUR CONSTITUTIF, STABLE ET À FORTE EXPRESSION POUR VACCIN THÉRAPEUTIQUE POUR CANCER DU COL ET LACTOBACILLE RECOMBINANT TRANSFORMÉ PAR LEDIT VECTEUR
KOOKMIN UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY;BIOLEADERS CORPORATION
发明人:
SUNG, MOON-HEE,POO, HARYOUNG,LEE, IL HAN
申请号：
EP10729333
公开号：
EP2386645A4
申请日:
2010.01.08
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The present invention relates to a surface expression vector for preparing HPV vaccines, in which the surface expression vector contains a gene encoding a repE mutant protein having an amino acid sequence of SEQ ID NO: 1, a promoter, a poly-gamma-glutamate synthetase complex gene, and a gene which is linked with the poly-gamma-glutamate synthetase complex gene and encodes a tumor induction-associated antigen protein of human papillomavirus. The present invention provides an expression vector constitutively expressing a high level of the human papillomavirus (HPV) antigen protein. Also, the invention provides recombinant lactic acid bacteria, transformed with the expression vector and expressing the HPV antigen protein on the surface thereof, and a composition comprising the recombinant lactic acid bacteria. The recombinant lactic acid bacteria and the composition are very effective as a vaccine for the treatment of cervical cancer, because they can be applied orally or directly to the vagina.
