Annika KRAEMER-KUEHL,Egbert Siegfried MUNDT,Hans-Christian PHILIPP
申请号：
US16665465
公开号：
US20200129614A1
申请日:
2019.10.28
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates i.a. to an H52 IBV (infectious bronchitis virus) encoding for a heterologous S (spike) protein or fragment thereof. Further, the present invention relates to an immunogenic composition comprising said H52 IBV encoding for a heterologous S (spike) protein or fragment thereof. Furthermore, the present invention relates to methods for immunizing a subject comprising administering to such subject the immunogenic composition of the present invention. Moreover, the present invention relates to methods of treating or preventing clinical signs caused by IBV in a subject of need, the method comprising administering to the subject a therapeutically effective amount of an immunogenic composition according to the present invention.
