Yuqiang Wang,Haiyun Chen,Zaijun Zhang,Gaoxiao Zhang,Pei Yu,Yewei Sun,Luchen Shan,Liang Tao
申请号：
US16501284
公开号：
US20190218192A1
申请日:
2019.03.19
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to trifluoroacetyl hydrazide compounds and medical uses thereof. The compounds have a structure of the following formula:The compounds showed multifunctional mechanisms, including inhibition of glutamate excitotoxicity, activation of MEF2 transcriptional activity, clearance of free radicals, and promotion of nerve differentiation, and has a better protective effect on cells especially nerve cells. The compound can be used to prepare prophylactic or therapeutic medicaments with cytoprotective effects, for the prevention or treatment of diseases related to glutamate receptor activation, MEF2 disorders or excessive free radicals generation. The diseases include, for example, neurodegenerative diseases such as Alzheimer's disease, Parkinson and stroke, and the free radicals related diseases such as heart disease, myocardial ischemia, diabetes and other cardiovascular and cerebrovascular diseases.
