A method for decomposing localized fat accumulation in a subject having localized fat accumulation comprising contacting the localized fat accumulation with a composition comprising 50-3,000 IU/mL of hyaluronidase, 0.01-9.9 wt % of sodium deoxycholate, and 0.01-0.89 wt % of sodium chloride solution, relative to the total weight of the composition. The composition need not contain phosphatidylcholine. The hyaluronidase and the sodium deoxycholate can be dissolved in a hypotonic solution for inducing physical decomposition of fat cells by an osmotic pressure difference.
