A hemodialysis machine defining a closed loop fluid path for dialysate solution, the fluid path comprising: a first pump chamber having a pump inlet and a pump outlet, a dialyser having a dialyser inlet and a dialyser outlet, a conduit connected between the outlet of the first pump chamber and the inlet of the dialyser, a second pump chamber having a pump inlet and a pump outlet, a conduit connected between the outlet of the dialyser and the inlet of the second pump chamber, a dialysate regeneration device having a filter inlet and a filter outlet, a conduit connected between the outlet of the second pump chamber and the inlet of the dialysate regeneration device, a reservoir having a reservoir inlet and a reservoir outlet, a conduit connected between the outlet of the dialysate regeneration device and the inlet of the reservoir and, a conduit connected between the outlet of the reservoir and the inlet of the first pump chamber.
