The present invention relates to immunotherapeutic peptides and their use inimmunotherapy, in particular the immunotherapyof cancer. The present invention discloses tumor-associated T-helper cellpeptide epitopes, alone or in combinationwith other tumor-associated peptides that serve as active pharmaceuticalingredients of vaccine compositions which stimulateanti-tumor immune responses. In particular, the composition of the peptides ofthe present invention can be used in vaccinecompositions for eliciting anti-tumor immune responses against gliomas.