Arrhythmia may impact the determination of physiological information from a physiological signal. A patient monitoring system may detect the presence of arrhythmia based on changes in the physiological signal. Derived value data sets may be extracted from the physiological signal and calculations performed to generate arrhythmia features. The arrhythmia features may be used to generate an arrhythmia indicator that may indicate the presence of arrhythmia in the physiological signal.