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TRP-M8 receptor ligands and their use in treatments
- 专利权人:
- Thomas Nguyen;Vijay K. Gore;Vu Van Ma;Matthew Kaller;Mark H. Norman;Nobuko Nishimura;Daniel Horne;Nuria Tamayo;Yunxin Y. Bo;Holger Monenschein
- 发明人:
- Mark H. Norman,Yunxin Y. Bo,Vijay K. Gore,Daniel Horne,Matthew Kaller,Vu Van Ma,Holger Monenschein,Thomas Nguyen,Nobuko Nishimura,Nuria Tamayo
- 申请号：
- US12746292
- 公开号：
- US08476297B2
- 申请日:
- 2008.12.04
- 申请国别(地区):
- US
- 年份:
- 2013
- 代理人:
- 摘要：
- Tetrahydroisoquinoline compounds of formula (I), and compositions containing them, for the treatment of acute, inflammatory and neurophatic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neurophatic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
