STUPPLE, Paul Anthony,WALKER, Scott Raymond,CAMERINO, Michelle Ang
申请号：
EPEP2017/055535
公开号：
WO2017/153518A1
申请日:
2017.03.09
申请国别(地区):
WO
年份:
2017
代理人:
摘要：
A compound of formula (Ia), (Ib) or (Ic) wherein: n is 1 or 2 RN is H or Me R1 is optionally one or more halo or methyl groups R2a and R2b are independently selected from the group consisting of: (i) F (ii) H (iii) Me and (iv) CH2OH R2c and R2d (if present) are independently selected from the group consisting of: (i) F (ii) H (iii) Me and (iv) CH2OH R3a and R3b are independently selected from H and Me R4a is selected from OH, -NH2, -C(=O)NH2, and -CH2OH R4b is either H or Me X is either N or CH R7 is selected from H and C1-4 alkyl (a) one of R8a, R8b, R8c and R8d is selected from H, halo, C1-4 alkyl, C1-4 alkoxy, NHC1-4 alkyl (b) another of R8a, R8b, R8c and R8d is selected from H, C1-4 alkyl, C1-4 fluoroalkyl, C3-6 cycloalkyl, C5-6 heteroaryl, C5-6 heteroaryl methyl, C4-6 heterocyclyl, C4-6 heterocyclyl methyl, phenyl, benzyl, halo, amido, amidomethyl, acylamido, acylamidomethyl, C1-4 alkyl ester, C1-4 alkyl ester methyl, C1-4 alkyl carbamoyl, C1-4 alkyl carbamoyl methyl, C1-4 alkylacyl, C1-4 alkylacyl methyl, phenylcarbonyl, carboxy, carboxymethyl, ether, amino, amino methyl, sulfonamido, sulfonamino, sulfone, sulfoxide, nitrile and nitrilemethyl (c) the others of R8a, R8b, R8c and R8d are H.Linvention concerne un composé de formule (Ia), (Ib) ou (Ic). n est 1 ou 2 RN est H ou Me R1 est éventuellement un ou plusieurs groupes halo ou méthyle R2a et R2b sont indépendamment choisis parmi le groupe constitué de ce qui suit : (i) F (ii) H (iii) Me et (iv) CH2OH R2c et R2d (sils sont présents) sont indépendamment choisis parmi le groupe constitué de ce qui suit : (i) F (ii) H (iii) Me et (iv) CH2OH R3a et R3b sont indépendamment choisis parmi H et Me R4a est choisi parmi OH, -NH2, -C(=O)NH2, et -CH2OH R4b est soit H, soit Me X est soit N, soit CH R7 est choisi parmi H et alkyle en C1-4 (a) un élément parmi R8a, R8b, R8c, et R8d est choisi parmi H, halo, alkyle en C1-4, alcoxy en C1-4, NHC1-4 alkyle (b) un autre élément parmi R8a, R8b, R8c et R8d est cho
