The Board of Trustees of the Leland Stanford Junior University
发明人:
Samuel Strober,Robert Lowsky
申请号：
US16723840
公开号：
US20200254015A1
申请日:
2019.12.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to an HLA mismatched recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
