RAPACKI, ALAN,RUBINCHIK, VALERY,HOLDS, JOHN,SIM, SYLVIE,SHEN, DANNY
申请号：
ES08829084
公开号：
ES2525125T3
申请日:
2008.09.05
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A tear implant insertable in a tear canaliculus, comprising: an implant body (302), which includes the first (304) and second portions (306), the implant body that extends from a proximal end (308) of the first portion to a distal end (310) of the second portion, the first portion that includes a cavity (318)； a medicament insert (322) disposed in the cavity, the medicament insert comprises a plurality of inclusions of therapeutic agents (360) distributed in a matrix (362) to provide sustained release of the agent, the proximal end of the first portion that defines a longitudinal proximal axis and the distal end of the second portion defining a longitudinal distal axis； The implant body configured so that, when implanted in the tear canaliculus, there is an inclined intersection between the proximal axis and the distal axis to press at least a portion of the implant body against at least a portion of the lacrimal canaliculus located at or more distal to a canalicular curvature； and wherein the second portion of the implant body includes a longitudinal length having a magnitude less than four times a longitudinal length of the first portion of the implant body, characterized in that the medicament insert is further provided with a disposed sheath body on at least a portion of the insert to define at least one exposed surface of the insert located at or near the proximal end of the first portion of the implant body.Un implante lagrimal insertable en un canalículo lagrimal, que comprende: un cuerpo de implante (302), que incluye las primera (304) y segunda porciones (306), el cuerpo de implante que se extiende desde un extremo proximal (308) de la primera porción a un extremo distal (310) de la segunda porción, la primera porción que incluye una cavidad (318)； un inserto de medicamento (322) dispuesto en la cavidad, el inserto de medicamento comprende una pluralidad de inclusiones de agentes terapéuticos (360) distribuidas en una matriz (362) para proporcionar la liber
