PROBLEM TO BE SOLVED: To provide a pharmaceutical composition, a food and drink composition or a food and drink additive, capable of reducing palatability to high fat diet, letting people eat low fat diet unconsciously and exhibiting a large effect on prevention of adult diseases such as obesity prevention, etc.SOLUTION: This pharmaceutical composition, food and drink composition or food and drink additive is provided by comprising γ-oryzanol or 4-phenylbutyric acid, which is a peculiar physiologically active substance in rice bran oil, rice germ oil, etc.