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INHIBITORS OF BRUTON'S TYROSINE KINASE
专利权人:
에프. 호프만-라 로슈 아게
发明人:
아이어 라만 마하데반,라인 드라만 이브라힘,로페즈-타피아 프란시스코 자비에르,필립스 조나단 이,스티븐슨 크리스토퍼
申请号:
KR1020157014170
公开号:
KR1020150075115A
申请日:
2013.11.27
申请国别(地区):
KR
年份:
2015
代理人:
摘要:
The present invention also relates to the use of the Btk inhibitor compound 6-tert-butyl-8-fluoro-2- {3-hydroxymethyl-4- [ 2, 3 ', 4', 5 ', 6'-hexahydro- [3,4'] bipyridinyl-6-ylamino) -6-oxo-1,6-dihydro- Yl} -2H-phthalazin-1-one, 2- (2- {3- [5- (5-Azetidin- 1 -ylmethyl-1-methyl-1H-pyrazole Yl] -2-hydroxymethyl-phenyl} -8-fluoro-1-oxo-1, 6-dihydro-pyridazin- 2-methyl-propionitrile and 6-tert-butyl-2- [2-hydroxymethyl-3- (5- {5 - [(2-methoxy -Ethylamino) -methyl] -pyridin-2-ylamino} -6-oxo-1,6-dihydro-pyridin- 3- yl) -phenyl] -3,4- dihydro-2H-isoquinoline- - on, their formulation, and methods of treating asthma.본 발명은 본원에 기술된 바와 같은 Btk 억제제 화합물 6-tert-부틸-8-플루오로-2-{3-하이드록시메틸-4-[1-메틸-5-(1'-메틸-1',2',3',4',5',6'-헥사하이드로-[3,4']바이피리딘일-6-일아미노)-6-옥소-1,6-다이하이드로-피리다진-3-일]-피리딘-2-일}-2H-프탈라진-1-온, 2-(2-{3-[5-(5-아제티딘-1-일메틸-1-메틸-1H-피라졸-3-일아미노)-1-메틸-6-옥소-1,6-다이하이드로-피리다진-3-일]-2-하이드록시메틸-페닐}-8-플루오로-1-옥소-1,2-다이하이드로-이소퀴놀린-6-일)-2-메틸-프로피오니트릴 및 6-tert-부틸-2-[2-하이드록시메틸-3-(5-{5-[(2-메톡시-에틸아미노)-메틸]-피리딘-2-일아미노}-6-옥소-1,6-다이하이드로-피리딘-3-일)-페닐]-3,4-다이하이드로-2H-이소퀴놀린-1-온, 이들의 제형, 및 천식의 치료 방법에 관한 것이다.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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