“A nutritional supplement composition suitable for improving lean tissue mass status in a mammal” A nutritional supplement suitable for increasing lean tissue mass in a mammal comprises protein, vitamin D, and calcium. The protein comprises a casein-based milk protein composition, a hydrolysed whey-based milk protein composition having insulinotropic bioactivity, and a hydrolysed whey-based milk protein composition having anti-oxidant bioactivity. The supplement increases lean tissue mass in a subject.