Hyeong Kyu Lee,Kyung Seop Ahn,Yoosik Yoon,Byoung Whui Choi,Ok-Kyoung Kwon,Semi Kim,Hui Seong Kim,Sei Ryang Oh,Ji Eun Yuk,Ha Young Jang
申请号：
US13807829
公开号：
US20130108652A1
申请日:
2011.07.01
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to a kit for the diagnosis or screening of asthma comprising neuropilin (NRP) gene, and to a method for screening a therapeutic agent for asthma using the same. More precisely, the present invention confirmed that NRP1 expression was increased in asthma patients and by D. pteronissinus extract. Based on the confirmation, the inventors confirmed that NRP1 could be effectively used as a target for the development of a therapeutic agent for asthma since the suppression of NRP1 expression resulted in the decrease of mRNA, protein, enzyme activity, and promoter activity of MMP-9 in relation to asthma.
