HICKSON JONATHAN A.,HAASCH DEANNA L.,GUPTA SUPRIYA,ZAMIRI CAMELLIA,GU JIJIE,AMBROSI DOMINIC J.,LAPPE SUSAN E.,LI YINGCHUN,NAUMOVSKI LOUIE,CAO XIANHUA,CHARI RAVI
申请号：
NZ70764113
公开号：
NZ707641A
申请日:
2013.10.31
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed herein are multivalent and multispecific binding proteins capable of binding DLL4 and VEGF, comprising SEQ ID NO: 56 and SEQ ID NO: 64. Also disclosed herein are methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases characterized by aberrant DLL4 and/or VEGF expression or activity.
