ANTICORPS BIVALENTS MASQUES PAR DES BOBINES ENROULEES

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专利权人:

SEATTLE GENETICS; INC.

发明人:

TRANG, VIVIAN,LEVENGOOD, MATTHEW R.,SENTER, PETER

申请号：

CA3042276

公开号：

CA3042276A1

申请日:

2017.12.08

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The invention provides bivalent antibodies including two light and heavy chain pairs. The N-termini of one or both light and heavy chain pairs are linked via linkers comprising a protease cleavage site to coiled-coil forming peptides that associate to form a coiled coil reducing binding affinity of at least one light-heavy chain pair to a target.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/