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Polypeptides for the treatment of diseases
专利权人:
Neopep Pharma GmbH & Co. KG
发明人:
FORSSMANN, Wolf-Georg
申请号:
AU2018328044
公开号:
AU2018328044A1
申请日:
2018.09.10
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
A polypeptide having the general amino acid sequence written in the single letter code Z1 I X2 R W X5 X6 K X8 P X10 X11 S Z3, wherein X2 = V, M or L, in particular L, X5 = S or T, X6 = K or R, in particular R, X8 = V, M, L or F, in particular M, X10 = Q or C, in particular C, X11 = V, M or F, in particular V; Z1 = 0, Z2, or pyro glutamate, wherein Z2 = is a modification of the N-terminal nitrogen atom of the peptide chain which modification forms together with the amino group of the N-terminal amino acid of the peptide a moiety having the structure -NR2R3 wherein R2 and/or R3 are independently from each other H or a substituted or unsubstitued acyl, alkyl, aryl, aralkyl, cyclo alkyl and heterocyclo alkyl group; Z3 = 0, or Z4, wherein Z4 = is a modification of the C-terminal carboxyl group of the peptide chain, which modification forms together with the carboxyl group of the C-terminal amino acid of the peptide a moiety having the structure -C(O)-O-R1 or -C(O)- NR2R3, wherein R1 is a substituted or unsubstitued alkyl, aryl, aralkyl, cyclo alkyl and heterocyclo alkyl group; and R2 and R3 are defined as above.
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