To provide methods, compositions and kits for treating intestinal hyperpermeability, including underlying diseases such as diabetes, autism, fibromyalgia, inflammatory bowel disease, graft versus host disease, HIV/AIDS, multiple organ dysfunction syndrome, irritable bowel syndrome, celiac disease, eczema, psoriasis, acute pancreatitis, Parkinson's disease, depression, chronic fatigue syndrome, asthma, multiple sclerosis, arthritis, ankylosing spondylitis, nonalcoholic fatty liver disease, alcoholic cirrhosis, environmental enteropathy, or kwashiorkor, and conditions such as hyperglycemia.SOLUTION: A method of treating intestinal hyperpermeability comprises administering to a subject in need thereof an effective amount of a tyrosine hydroxylase inhibitor. The method further comprises administering a p450 3A4 promoter.SELECTED DRAWING: None【課題】高血糖症等の状態、並びに糖尿病、自閉症、線維筋痛症、炎症性腸疾患、移植片対宿主病、ＨＩＶ／ＡＩＤＳ、多臓器不全症候群、過敏性腸症候群、小児脂肪便症、湿疹、乾癬、急性膵炎、パーキンソン病、鬱病、慢性疲労症候群、喘息、多発性硬化症、関節炎、強直性脊椎炎、非アルコール性脂肪性肝疾患、アルコール性肝硬変、環境性腸症、又はクワシオルコル等の基礎疾患を含む、腸透過性亢進を治療するための方法、組成物、及びキットの提供。【解決手段】腸透過性亢進を治療する方法であって、それを必要とする対象に有効量のチロシンヒドロキシラーゼ阻害剤を投与することを含む方法。ｐ４５０ ３Ａ４促進剤を投与することを更に含む前記方法。【選択図】なし
