（Ｓ）－２－（１－（６－胺基－５－氰基嘧啶－４－基胺基）乙基）－４－側氧基－３－苯基－３，４－二氫吡咯并［１，２－Ｆ］［１，２，４］三嗪－５

发明人:: CARRERA CARRERA, FRANCESC,卡雷拉卡雷拉　弗朗切斯科,PEREZ GARCIA, JUAN BAUTISTA,佩雷兹加西亚　胡安鲍蒂斯塔,佩雷茲加西亞　胡安鮑蒂斯塔,VIDAL JUAN, BERNAT,米多琼　伯奈特,米多瓊　伯奈特,SANCHEZ IZQUIERDO, FRANCISCO,桑切斯伊兹基耶多　法兰西斯科,桑切斯伊茲基耶多　法蘭西斯,卡雷拉卡雷拉弗朗切斯科,佩雷兹加西亚胡安鲍蒂斯塔,佩雷茲加西亞胡安鮑蒂斯塔,米多琼伯奈特,米多瓊伯奈特,桑切斯伊兹基耶多法兰西斯科,桑切斯伊茲基耶多法蘭西斯

摘要：: The present invention is directed to novel pharmaceutically acceptable, addition salts of (S)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-4-oxo-3-phe nyl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile with sulfonic acid derivatives, in particular with methanesulfonic acid, naphthalene-2-sulfonic acid and para-toluenesulfonic acid, and pharmaceutically acceptable solvates thereof, and their use as Phosphoinositide 3-Kinase (PI3K) inhibitors.本發明係針對一種新穎之醫藥上可接受之加成鹽類，其係(S)-2-(1-(6-胺基-5-氰基嘧啶-4-基胺基)乙基)-4-側氧基-3-苯基-3,4-二氫吡咯并[1,2-f][1,2,4]三嗪-5-腈與磺酸衍生物，尤其是與甲磺酸、萘-2-磺酸及對甲苯磺酸；及其醫藥上可接受之溶劑合物；以及其作為磷酸肌醇3-激酶(PI3K)抑制劑之用途。