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NANOPARTICLE-MEDIATED GENE DELIVERY, GENOMIC EDITING AND LIGAND-TARGETED MODIFICATION IN VARIOUS CELL POPULATIONS
专利权人:
RENSSELAER POLYTECHNIC INSTITUTE
发明人:
Shiva Prasad KOTHA,Andre Ronald WATSON,Vaibhav A. PANDIT
申请号:
US16697308
公开号:
US20200181642A1
申请日:
2019.11.27
申请国别(地区):
US
年份:
2020
代理人:
摘要:
An improved nanoparticle for transfecting cells is provided. The nanoparticle includes a core polyplex and a silica coating on the core polyplex and, optionally, a polymer attached to an outer surface of the silica coating, where the polyplex includes an anionic polymer, a cationic polymer, a cationic polypeptide, and a polynucleotide. Also provided is an improved method of modifying intracellular polynucleotides. The method includes contacting a cell with a nanoparticle that includes a core polyplex and a silica coating on the core polyplex and, optionally, a polymer attached to an outer surface of the silica coating, where the polyplex includes an anionic polymer, a cationic polymer, a cationic polypeptide, and a polynucleotide.
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http://www.ckcest.cn/home/

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