Mateo De Acosta Del Rio, Cristina Maria,Vazquez Lopez, Ana Maria,Lopez Requena, Alejandro,Fernandez Marrero, Yuniel,Soto Lopez, Yosdel,Brito Navarro, Victor
申请号：
AU2010244859
公开号：
AU2010244859B2
申请日:
2010.05.03
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention relates to the field of biotechnology and particularly to novel products for use in human health. The present invention provides novel monoclonal antibodies that specifically and with high affinity recognize sulphatides and sulphated proteoglycans. The anti-sulphatide and anti-sulphated proteoglycan antibodies described in the present specification constitute important diagnostic and therapeutic agents for acting on pathological processes associated with the appearance of atherosclerotic plaques. According thereto, the invention provides pharmaceutical compositions that comprise the monoclonal antibodies of the invention or fragments derived from these antibodies for therapeutic and diagnostic use in association with cardiovascular diseases. Additionally, the present invention relates to fragments of the monoclonal antibodies that recognize sulphatides and sulphated proteoglycans, such that said fragments may be used in the treatment or diagnosis of this pathological condition.
