Samuel C. Wagner,Thomas E. Ichim,Julia S. Szymanski,Santosh Kesari,Amit N. Patel,Boris Minev
申请号：
US15048922
公开号：
US20170151281A1
申请日:
2016.02.19
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The current invention provides monocytic cells transfected with chimeric antigen receptor (CAR) to selectively home to tumors and upon homing differentiate into dendritic cells capable of activating immunity which is inhibitory to said tumor. In one embodiment of the invention, monocytic cells are transfected with a construct encoding an antigen binding domain, a transcellular or structural domain, and an intracellular signaling domain. In one specific aspect of the invention, the antigen binding domain interacts with sufficient affinity to a tumor antigen, capable of triggering said intracellular domain to induce an activation signal to induce monocyte differentiation into DC.
