The present invention relates to novel carboxylic acid derivatives of 11-oxo-11H-pyrido[2,1-b]quinazoline-6-carboxamide as potent inhibitors of protein kinases, pharmaceutical compositions containing these derivatives, and protein kinases. It relates to the use of said compound for the manufacture of a medicament for the treatment of a pathological condition or disorder ameliorated by inhibition. [Selection diagram] None本発明はプロテインキナーゼの強力な阻害剤としての11-オキソ-11H-ピリド[2,1-b]キナゾリン-6-カルボキサミドの新規カルボン酸誘導体、それらの誘導体を含む医薬組成物、及びプロテインキナーゼの阻害により改善される病態又は疾患の治療用の医薬の製造への前記化合物の使用に関する。【選択図】なし