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DÉRIVÉ DE 1,3-DI-OXO-INDÈNE, SON ISOMÈRE OPTIQUE OU SON SEL PHARMACEUTIQUEMENT ACCEPTABLE, SON PROCÉDÉ DE PRÉPARATION ET COMPOSITION PHARMACEUTIQUE LE CONTENANT EN TANT QUE PRINCIPE ACTIF ANTIVIRAL
专利权人:
Korea Research Institute of Chemical Technology;Katholieke Universiteit Leuven
发明人:
申请号:
EP19179546.7
公开号:
EP3611158A1
申请日:
2012.06.18
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
Disclosed are 1,3-Dioxoindene derivatives of Formula 1, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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