Influenza virus replication inhibitors农业专利-农业专业知识服务系统

发明人:: K．W．恩蒂阿达,K．W．恩蒂阿達,M．沃尔多,M．沃爾多,S．A．奥尼尔,S．A．奧尼爾,J．G．范阿尔斯藤,J．G．范阿爾斯藤,D．马奇克纳斯,D．馬奇克納斯,P．穆杜努里,施谊,施誼,M．W．里德博尔,M．W．里德博爾,V．尤尔卡斯卡斯,V．尤爾卡斯卡斯,A．梅德克,S．琼斯,S．瓊斯,R．伯恩,M．阿斯摩,S．M．罗伯逊,S．M．羅伯遜,蔡婉

摘要：: The polymorphic form of compound (1) or pharmaceutically acceptable salt thereof, wherein compound (1) expressed as the following structural formula is HCl salt of compound (1)·form a of 1 / 2H2O, HCl salt of compound (1)·form F of 3H2O, HCl salt of compound (1) form D, form a of compound (1) and toluene sulfonate of compound (1). These polymorphisms are used to treat influenza in biological samples or subjects, inhibit the replication of influenza virus or reduce the amount of influenza virus.化合物(1)或其藥學上可接受的鹽的多晶型，其中表示爲如下結構式的化合物(1)，是化合物(1)的HCl鹽•1/2H2O的形式A、化合物(1)的HCl鹽•3H2O的形式F、化合物(1)的HCl鹽的形式D、化合物(1)的形式A和化合物(1)的甲苯磺酸鹽的形式A。這類多晶型用於治療生物樣品或受試者中的流感、抑制其流感病毒複製或减少其流感病毒的量。