INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;인제대학교 산학협력단
发明人:
SEOL, WON GI,설원기,HA, IL HO,하일호,YUN, HEY JIN,윤혜진
申请号：
KR1020100083226
公开号：
KR1020120019785A
申请日:
2010.08.27
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A composition containing a compound with an activity of suppressing LRRK2 kinase is provided to suppress oxidative stress cytotoxicity and to prevent or treat Parkinson's disease. CONSTITUTION: A pharmaceutical composition for preventing or treating Parkinson's disease contains a compound of chemical formula 1 as an active ingredient. A pharmaceutical composition for preventing or treating Parkinson's disease contains the compound of chemical formula 1 as an active ingredient. The compound of chemical formula 1 is (E)-4-((2-(4-methylquinoline-2-yl)hydrazono)methyl)benzene-1,2-diol or (E)-4-methyl-2-(2-(pyridine-4-ylmethylene)hydrazinyl)quinoline. The compound is LRRK2(leucine rich repeat kinase 2) inhibitor. A health food for treating Parkinson's disease contains the compound of chemical formula 1 as an active ingredient.본 발명은 LRRK2 인산화효소 억제 활성을 갖는 화합물을 유효성분으로 함유하는 파킨슨병 치료 또는 예방용 조성물에 관한 것으로, 상기 화합물은 LRRK2 인산화효소 억제제로서, LRRK2 돌연변이 단백질 과발현에 의한 산화적 스트레스 유도성 세포독성을 억제할 수 있기 때문에 파킨슨병 치료 또는 예방용 약제나 식품으로써 유용하게 사용될 수 있다.
