An integrated bioinformatics sensing apparatus includes a piezoelectric sensing layer, an upper conductive layer, a bottom conductive layer and an information transmission controller. The piezoelectric sensing layer senses a physiological rhythm of a living organism to output a physiological rhythm signal, and the upper and bottom conductive layers sense a physiological electrical signal on a body surface of the living organism. The information transmission controller receives and processes the physiological rhythm signal and the physiological electrical signal to generate and store the sensed bioinformatics, or transmit the signals to the external processing device to display the sensed bioinformatics. The simple-structured sensing apparatus can be attached onto the body surface of the living organism conveniently.