PROBLEM TO BE SOLVED: To provide a prophylactic/ameliorative agent for hydrogen peroxide-related cytotoxicity, a glutathione production promoter, an antioxidant, a tumor necrosis factor (TNF-&alpha) production inhibitor, a hexosaminidase-release inhibitor, a cyclooxygenase-2 inhibitor or an anti-inflammatory agent, based on having found a substance as an active ingredient for the agents, which has excellent prophylactic/ameliorative effect on hydrogen peroxide-related cytotoxicity, glutathione production-promoting effect, antioxidant effect, TNF-&alpha production inhibitory effect, hexosaminidase-release inhibitory effect, cyclooxygenase-2 inhibitory effect or anti-inflammatory effect, respectively.SOLUTION: The prophylactic/ameliorative agent for hydrogen peroxide-related cytotoxicity, the glutathione production promoter, the antioxidant, the tumor necrosis factor (TNF-&alpha) production inhibitor, the hexosaminidase-release inhibitor, the cyclooxygenase-2 inhibitor or the anti-inflammatory agent are each included with davidigenin as an active ingredient for the respective agents.COPYRIGHT: (C)2012,JPO&INPIT【課題】優れた過酸化水素細胞障害の予防・改善作用、グルタチオン産生促進作用、抗酸化作用、腫瘍壊死因子(TNF-α)産生抑制作用、ヘキソサミニダーゼ遊離抑制作用、シクロオキシゲナーゼ-2阻害作用又は抗炎症作用を有する物質を見出し、それを有効成分とする過酸化水素細胞障害の予防・改善剤、グルタチオン産生促進剤、抗酸化剤、腫腫瘍壊死因子(TNF-α)産生抑制剤、ヘキソサミニダーゼ遊離抑制剤、シクロオキシゲナーゼ-2阻害剤又は抗炎症剤を提供する。【解決手段】過酸化水素細胞障害の予防・改善剤、グルタチオン産生促進剤、抗酸化剤、腫腫瘍壊死因子(TNF-α)産生抑制剤、ヘキソサミニダーゼ遊離抑制剤、シクロオキシゲナーゼ-2阻害剤又は抗炎症剤の有効成分として、ダビジゲニンを含有させる。【選択図】なし
