An ergonomic scalpel having an elongate body with first end including a blade, and a second end, with the body having a substantially rounded triangular shape in cross section throughout. An elastomeric grip section is proximate to the first end that includes a maximum width of the body, and the body tapers therefrom to the second end. A generally rectangular blade is fastened, either fixedly or removably, to the first end of the body and has a height thereof. The maximum width of the body in the elastomeric grip section is greater than the height of the blade.