OX40L fusion proteins and uses thereof

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专利权人:

MEDIMMUNE; LLC

发明人:

Melissa Damschroder,Michael Oberst,Scott Hammond,Hui Feng

申请号：

US14722679

公开号：

US09718870B2

申请日:

2015.05.27

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The disclosure provides OX40L huIgG4 fusion polypeptide subunits comprising a human IgG4 Fc domain, a trimerization domain, and the receptor binding domain of Ox40 ligand, where the fusion polypeptide subunits can self-assemble into hexameric proteins. Also provided are methods of making fusion polypeptide subunits and hexameric proteins, and methods of use, e.g., treatment of cancer.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/