Willemsen, Ralph Alexander,Renes, Johan,Steverink, Paul
申请号：
NZ72216713
公开号：
NZ722167A
申请日:
2013.06.26
申请国别(地区):
NZ
年份:
2019
代理人:
摘要：
The present invention discloses that targeting infected cells for killing those infected cells can be achieved by providing a proteinaceous molecule comprising a single polypeptide chain comprising at least two specific binding domains separated by at least one linker further comprising an Fc monomer separated from said at least two specific binding domains by at least one linker, wherein said binding domains are Vh domains which specifically recognize a hepatitis C virus derived peptide in the context of MHC-1. More generally, the present invention relates to proteinaceous molecules comprising multiple recombinant antibody-fragments assembled at the DNA level into a single chain, which specifically bind hepatitis C virus derived peptide in the context of MHC-1. In addition, the invention relates to methods of diagnosing and treatment of infectious disease using these recombinant single-chain polypeptides.
