Antibodies and fragments thereof which bind to peptide-MHC complexes are disclosed, in particular peptide-MHC complex comprising a peptide of p53 and MHC class I molecule. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.揭示與胜肽-MHC複合體結合之抗體及其片段,尤其是包含一p53胜肽與MHC第I類分子之胜肽-MHC複合體。亦揭示包含該等抗體與片段之組成物,及其等的用途與使用方法。