Embodiments of a method and/or system for characterizing physiological metrics can include: collecting temperature data from a set of temperature sensors associated with at least one heat flux channel of a temperature monitoring device configured to couple to an exterior region of a user; extracting a perfusion parameter based on the temperature data; determining a core body temperature measurement (and/or other suitable physiological metric) based on the perfusion parameter; and/or characterizing a user condition (e.g., fever) based on the core body temperature measurement (and/or other suitable physiological metric).