Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):揭示用於預防及/或治療疾病之化合物、組成物及方法,該疾病病理生理學上係由神經激肽(neurokinin;NK1)受體所媒介。該化合物具有通式(I):