KSHIRSAGAR RAJESH,MUNDADE SACHIN,SHINDE GANESH,KAMBLE PRAVIN,MUDDA SM
申请号：
IN3193/CHE/2009
公开号：
IN2009CH03193A
申请日:
2009.12.29
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The present invention provides an extended release pharmaceutical composition suitable for once daily dosing comprising Linezolid or pharmaceutically acceptable salt, derivative, prodrug, metabolite and polymorph thereof and one or more pharmaceutically acceptable excipients and a process of preparing the same. The present invention further provides a method of treating bacterial infections in a mammal comprising administering an extended release, pharmaceutical composition suitable for once daily dosing comprising Linezolid capable of maintaining T>MIC for at least 24 hours. The present invention further provides an extended release pharmaceutical composition suitable for once daily dosing comprising Linezolid so that upon oral administration the maximum concentrations (Cmax) of Linezolid in plasma are statistically significantly lower than the immediate release formulation given twice daily, and area under the plasma concentration-time curve (AUC) and the minimum plasma concentrations are maintained over 24 hours.
