Nutraceutical composition for the activation of sirtuins in humans, said composition being characterized in that it comprises from 10% by weight to 15% by weight of honokiol； from 12% by weight to 40% by weight of pterostilbene； from 22% by weight to 32% by weight of polydatin； from 25% by weight to 40% by weight of ellagic acid and from 1.5% by weight to 3% by weight of a mixture of zinc, seleniun, chromium and nicotinamide, said composition promoting the inhibition of cell degradation and aging phenomena.
