The object of the present invention is to provide one kind can have required bioactivity and required radiation impermeability, while can keep the bone cement compositions of the intensity of its cured article. Coating of titanium dioxide is formed on radiation impermeability particle, composite particles are thus made, and the composite particles are added in bone cement compositions. Thus obtained bone cement compositions can be suitably with what filling bone defective section, fixed joint prosthesis and in what vertebroplasty. The radiation impermeability particle is respective to be preferably shaped to granular, and the titanium dioxide is preferably rutile-type.本發明的目的是提供一種可具有所需的生物活性和所需的輻射不透性，同時可保持其固化産品的強度的骨水泥組合物。在輻射不透性顆粒上形成二氧化鈦塗層，由此製得複合顆粒，並將所述複合顆粒添加至骨水泥組合物中。由此製得的骨水泥組合物可合適地用於填充骨缺陷部分、固定人工關節和用於椎體成形術中。所述輻射不透性顆粒各自的形狀優選爲粒狀，且所述二氧化鈦優選爲金紅石型。
