A stabilized 1,25 -dihydroxy vitamin D2 composition, free of methyl formate,which is particularly well suited forpharmaceutical formulations, pharmaceutical formulations of the 1,25 -dihydroxyvitamin D2 composition, and a method ofmaking the purified composition by purifying a crude 1,25 -dihydroxy vitaminD2 from acetone/water, are disclosed. The stabilized1,25 -dihydroxy vitamin D2 is characterized by a reduced rate of degradationon heat challenge and during prolonged storage andexhibits excellent storage stability when formulated in a pharmaceuticaldosage form, e.g., a soft gelatin capsule.
