Disclosed is the use of an antiplatelet thrombolysin in the preparation of a medicine for treating thrombotic thrombocytopenic purpura (TTP). The main pathogenesis of TTP is a von Willebrand factor-cleaving protease, namely, a congenital defect in ADAMTS13 expression or inhibition of ADAMTS13 expression by an autoantibody, thereby resulting in the aggregation of a large number of von Willebrand factors (vWFs)