Alexander Pasternak;Barbara Pio;Aurash Shahripour;Shawn Walsh;Haifeng Tang
发明人:
Barbara Pio,Alexander Pasternak,Aurash Shahripour,Haifeng Tang,Shawn Walsh
申请号:
US14364908
公开号:
US09206199B2
申请日:
2012.12.11
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention provides compounds of Formula Iand the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.