The present invention relates to a kind of pharmaceutical composition, take gender for treating, preventing or improving premature ejaculation before can according to need, and including 14 to 16mg HCI clomipramines, preferably from about 15mg, as active constituent. It is further preferred that composition of the invention further include: pregelatinized starch； And sodium starch glycollate. Effect is quickly presented in pharmaceutical composition of the invention, has gastrointestinal tract pH level caused by low dissolution (absorption) the change of divergence, and have extremely low side effect.
