МАКВИРТЕР, Джон (US),МАКДОНАЛД, Линн (US),МЕРФИ, Эндрю, Джей. (US)
申请号：
RU2019121863
公开号：
RU2019121863A
申请日:
2014.09.18
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
A genetically modified non-human animal is provided, wherein the non-human animal expresses an antibody repertoire capable of pH dependent binding to antigens upon immunization. A genetically modified non-human animal is provided that expresses human immunoglobulin light chain variable domains derived from a limited repertoire of human immunoglobulin light chain variable gene segments that comprise histidine modifications in their germline sequence. Methods of making non-human animals that express antibodies comprising histidine residues encoded by histidine codons introduced into immunoglobulin light chain nucleotide sequences are provided.
