NOUVELLE UTILISATION DE LA PROTEINE 3 MULTIFONCTIONNELLE INTERAGISSANT AVEC L'AMINOACYL-TARN SYNTHASE (AIM3) COMME SUPPRESSEUR TUMORAL

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专利权人:

Medical Bioconvergence Research Center

发明人:

申请号：

EP04774463.6

公开号：

EP1617875B1

申请日:

2004.09.01

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The present invention relates to novel uses of AIM3 acting as a tumor suppressor, and more particularly to methods for using an AIM3 protein or a nucleic acid encoding the protein to activate ATM or ATR and to treat ATM- or ATR-mediated diseases. The AIM3 protein according to the present invention interacts directly with ATM/ATR so as to activate ATM/ATR and proteins regulated by ATM/ATR. Also, the AIM3 protein upregulates tumor suppressor gene p53 and its target genes so as to not only inhibit the proliferation of cells but also to induce apoptosis.

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中国工程科技知识中心

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http://www.ckcest.cn/home/